Patient Zero is a Demon Unique ring with no boss attached: it drops anywhere in Hell, most often from H1 up (rarer below that home difficulty, never above it), and nowhere else. Every copy is item level 110, and there 0.2% of what falls comes up Unique. It is built on Immaculate Venomglass Ring — step 6 of the Venomglass Ring line, item level 80 and up.

It always rolls the same numbers: +20 Power, +14% Poison Damage, +20% Venom Effect, +594 Maximum Health, +42% Venom Effect and +42% Poison Damage.

One Unique drop in 40 is a Mythical copy: the same item carrying 15–25% Mythical Energy that boosts every stat on it and can never be changed; the 15% floor is 10 times as common as the perfect 25%.

On top of that it carries Patient Zero — A Venomed enemy's death spreads its Venom to nearby enemies.

“Nobody remembers the first cough.”