Updated 2 Oct 2026
Affixes/Poison Damage

Poison Damage is a prefix that turns up on Main Hand, Off Hand and Ring. It gives Poison Damage: +3% to +4% at its lowest step, +39% to +44% at its best — and you need item level 116 before the best one can appear at all.

It comes up at weight 6 when the game rolls affixes, never doubles up with another affix that does the same job (affinity_damage), and it is what puts Tainted, Noxious, Toxic, Virulent and Pestilent in an item's name — so you might pick up a Tainted Wand.

11 Uniques lock it to a fixed number: The Slow Fang, Patient Zero, The Rot Ledger, Widow's Portion, Clutch of Eyes and Spinneret and 5 more.

Every step

10 steps · lowest to best
TierNeeds item levelGivesPrefix wordReads as
T11+3% to +4%TaintedTainted Wand
T26+5% to +7%TaintedTainted Wand
T314+8% to +10%NoxiousNoxious Wand
T424+11% to +13%NoxiousNoxious Wand
T536+14% to +17%ToxicToxic Wand
T655+18% to +24%ToxicToxic Wand
T775+25% to +28%VirulentVirulent Wand
T892+29% to +32%VirulentVirulent Wand
T9105+33% to +38%PestilentPestilent Wand
T10116+39% to +44%PestilentPestilent Wand

Where you will see it

388 bases it can land on

Uniques that lock it in

all 11 →